Pulmonary Hypertension

With the participation of over 20 international centers, this study investigates the clinical relevance of pulmonary exercise hemodynamics. To date, the individual values of over 2,000 patients have been entered into the PEX-NET registry. The project is supported by the European Respiratory Society. The initial results were published at the end of 2024, and since then, work has continued on several specific issues.

With the participation of five international centers, the clinical relevance of pulmonary hemodynamics in patients with COPD is being investigated. The establishment of the registry began at the end of 2025. Our goal is to include and evaluate data from more than 1,000 patients in the registry by the end of 2026.

This study analyzes different COPD phenotypes and evaluates their prognosis and response to PH medications. As part of the study, CT chest images will also be analyzed using special software, and the pulmonary vessels will be segmented. The study is being conducted in collaboration with Brigham and Women's Hospital and Harvard Medical School (Boston, Massachusetts, USA), as well as The University of Maryland - Institute for Health Computing (Bethesda, MD, USA).

This study examines the spectrum of patients with interstitial lung diseases and pulmonary vascular diseases. The aim of the study is to develop optimal treatment strategies for individual phenotypes.

To date, more than 300 patients at risk of developing interstitial lung disease have been included in this prospective study. The patients are monitored every 6-12 months. The aim of the study is to develop an algorithm for the early detection of interstitial lung disease and to identify biomarkers that predict the development of interstitial lung disease.

This prospective study included 55 patients prior to planned kidney transplantation. The aim of the study is to investigate pulmonary hemodynamics in these patients before and after kidney transplantation and to identify prognostically relevant parameters.

This database includes patients who are clinically examined at our clinic for suspected pulmonary hypertension and are characterized in detail. The database currently contains the clinical data of more than 4,500 patients.

In this study, standard values for pulmonary hemodynamics are determined and interpreted using meta-analyses based on the available published literature. Our current analyses focus on pulmonary vascular compliance.

In addition to our own initiatives, we support several international scientific projects investigating various clinical and scientific issues. Without being able to mention them all, we would like to highlight our participation in the COMPERA Registry and the GoDeep Registry, as well as our collaboration with PAH-ICON and Heidelberg University on genetic issues in the field of pulmonary hypertension.

• Bohr Bernd
• Douschan Philipp
• Eichtinger Iris Katharina
• Huemer Anna
• John Teresa
• Kleinschek Daniela
• Kücükyasar Zara
• Pavlovic Ilijana
• Reichholf Laura
• Ruppert Gina Louisa
• Zeder Katarina Eleonora